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What is diabetes?
Diabetes is a disease in which blood glucose levels
are above normal. Most of the food we eat is turned
into glucose, or sugar, for our bodies to use for
energy. The pancreas, an organ that lies near the
stomach, makes a hormone called insulin to help
glucose get into the cells of our bodies. When you
have diabetes, your body either doesn't make enough
insulin or can't use its own insulin as well as it
should. This causes sugar to build up in your blood.
Diabetes can cause serious health complications
including heart disease, blindness, kidney failure,
and lower-extremity amputations. Diabetes is the
sixth leading cause of death in the United States.
What are the symptoms of diabetes?
People who think they might have diabetes must visit
a physician for diagnosis. They might have SOME or
NONE of the following symptoms:
Frequent urination
Excessive thirst
Unexplained weight loss
Extreme hunger
Sudden vision changes
Tingling or numbness in hands or feet
Feeling very tired much of the time
Very dry skin
Sores that are slow to heal
More infections than usual.
What are the types of diabetes?
Type 1 diabetes, which was previously called
insulin-dependent diabetes mellitus (IDDM) or
juvenile-onset diabetes, may account for 5% to 10%
of all diagnosed cases of diabetes. Type 2 diabetes,
which was previously called non-insulin-dependent
diabetes mellitus (NIDDM) or adult-onset diabetes,
may account for about 90% to 95% of all diagnosed
cases of diabetes. Gestational diabetes is a type of
diabetes that only pregnant women get. If not
treated, it can cause problems for mothers and
babies. Gestational diabetes develops in 2% to 5% of
all pregnancies but usually disappears when a
pregnancy is over. Other specific types of diabetes
resulting from specific genetic syndromes, surgery,
drugs, malnutrition, infections, and other illnesses
may account for 1% to 2% of all diagnosed cases of
diabetes.
What are the risk factors for diabetes?
Risk factors for type 2 diabetes include older age,
obesity, family history of diabetes, prior history
of gestational diabetes, impaired glucose tolerance,
physical inactivity, and race/ethnicity. African
Americans, Hispanic/Latino Americans, American
Indians, and some Asian Americans and Pacific
Islanders are at particularly high risk for type 2
diabetes. Risk factors are less well defined for
type 1 diabetes than for type 2 diabetes, but
autoimmune, genetic, and environmental factors are
involved in developing this type of diabetes.
Gestational diabetes occurs more frequently in
African Americans, Hispanic/Latino Americans,
American Indians, and people with a family history
of diabetes than in other groups. Obesity is also
associated with higher risk. Women who have had
gestational diabetes are at increased risk for later
developing type 2 diabetes. In some studies, nearly
40% of women with a history of gestational diabetes
developed diabetes in the future.
Other specific types of diabetes, which may account
for 1% to 2% of all diagnosed cases, result from
specific genetic syndromes, surgery, drugs,
malnutrition, infections, and other illnesses.
Is there a cure for diabetes?
In response to the growing health burden of
diabetes, the diabetes community has three choices:
prevent diabetes; cure diabetes; and improve the
quality of care of people with diabetes to prevent
devastating complications. All three approaches are
actively being pursued by the US Department of
Health and Human Services. Both the National
Institutes of Health (NIH) and the Centers for
Disease Control and Prevention (CDC) are involved in
prevention activities. The NIH is involved in
research to cure both type 1 and type 2 diabetes,
especially type 1. CDC focuses most of its programs
on being sure that the proven science is put into
daily practice for people with diabetes. The basic
idea is that if all the important research and
science are not applied meaningfully in the daily
lives of people with diabetes, then the research is,
in essence, wasted.
Several approaches to "cure" diabetes are being
pursued:
Pancreas transplantation
Islet cell transplantation (islet cells produce
insulin)
Artificial pancreas development
Genetic manipulation (fat or muscle cells that don’t
normally make insulin have a human insulin gene
inserted — then these "pseudo" islet cells are
transplanted into people with type 1 diabetes).
Each of these approaches still has a lot of
challenges, such as preventing immune rejection;
finding an adequate number of insulin cells; keeping
cells alive; and others. But progress is being made
in all areas.
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